Christopher Guest Nigel Tufnel Mira Sorvino Meg Kennedy Mariah Carey Raychel Michael McKean David St. Hubbins Harry Shearer Derek Smalls Melora Walters Kate Arthur J. Nascarella Mr. Santalino Rob Reiner Marty DiBergi Paul Shaffer Artie Fufkin Saul Stein Umberto Joseph Siravo Gio Esposito Fran Drescher Bobbi Flekman Christian Maelen Frankie Santalino Noam Jenkins Garcia Peter Baylis Collegiate Man Chris Addison Simon Howler Tina Bruno Mrs. Saladino Kerry Godliman Hope Faith Nina Conti Moira John Michael Higgins Bob Kitness June Chadwick Jeanine Pettibone Griffin Matthews Peter La Pierre Kathreen Khavari Yasmine Farangi Don Lake Tour Guide CJ Vanston Caucasian Jeff Jean Cromie Oxygen Jason 'Wee Man' Acuña Damien The Druid Brad Williams Daniel The Druid Anthony Alessandro Lorenzo Louis Di Bianco Deluca Valerie Franco Didi Crockett Jeremiah Sparks Detective Levine Dax Ravina Tony Karen Giordano Angela Fontaine Michael Egan Joey Jr. Jere Gillis No Nose Steve Alonso DEA Officer Isa Thomas Grandmother Nell Jan Glenham Cadaver Lisa Ward Frankie's Girlfriend Lisa Croft Bartender Rudolfo Meloni Restaurant Patron Omar Corsetti Bar Patron Dimitri Iatrou Bar Patron